irrevocable – not able to be recovered, regained or remedied
(Pronounced ih-reh-vuh-kuh-buhl)
To remember the definition of the word irrevocable, use the following mnemonic:
He was irreplaceable, his vocals were not able (irrevocable) to be replaced. The band were not able to regain or recover their fame.

Examples of irrevocable in a sentence
Take your time and think about this irrevocable decision you are about to make.
Once the president signs the treaty, it will be binding and irrevocable.
While I hate to miss your wedding, I have irrevocable appointments I cannot reschedule.