Out, damned spot! Out, I say!

To remember this quote use the following mnemonic.

Out damned spot. 

"Out, damned spot! Out, I say!" Act 5, scene 1, line 31

Note: We have used a beaver in this picture to remind you that an important word is damned. The beaver just wants to get back to her "damned" river.

Lady Macbeth is walking and talking in her sleep, having nightmares about the assassination of King Duncan. As she walks she rubs her hands as though washing them. She is observed by a lady in waiting and a doctor who watch this and over hear her confession of regicide. 

The line is spoken and the way she acts symbolizes her guilt over the murders. The damned spot refers to the blood that she believes is still on her hands, representing her overwhelming guilt and the inescapability of her conscience. The line captures her descent into madness and highlights the theme of guilt and its psychological effects.